Exploiting AML vulnerability: glutamine dependency
نویسندگان
چکیده
منابع مشابه
Exploiting AML vulnerability: glutamine dependency.
In this issue of Blood, Jacque et al demonstrate that acute myeloid leukemia (AML) cells are selectively susceptible to disruption of glutamine metabolism through pharmacologic or genetic inhibition of the enzyme glutaminase C (GAC). The second law of thermodynamics states that the entropy, or simply chaos, of any system in the universe will always increase over time. Then, how are cancer cells...
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Cancer cells require nutrients and energy to adapt to increased biosynthetic activity and depend on mitochondrial oxidative phosphorylation (OXPHOS) and glycolysis. Whereas they exhibit a pronounced Warburg effect, their TCA cycle remains intact and becomes more dependent on glutamine metabolism through glutaminolysis[1]. Besides this role, intracellular glutamine is also essential for mTORC1 a...
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ژورنال
عنوان ژورنال: Blood
سال: 2015
ISSN: 0006-4971,1528-0020
DOI: 10.1182/blood-2015-07-659508